Turkish Journal of Anaesthesiology & Reanimation
Orthopaedic Anaesthesia - ORIGINAL ARTICLE

Effects of calcitonin addition on epidural injection in patients with degenerative spinal canal stenosis: a randomized double blind clinical trial

1.

Pain Research Center, Iran University of Medical Sciences, Tehran, Iran

2.

Department of Orthopedic Surgery, Iran University of Medical Sciences, Tehran, Iran

3.

Department of Anesthesiology, Ahwaz University of Medical Sciences, Ahwaz, Iran

4.

Department of Neurosurgery, Iran University of Medical Sciences, Tehran, Iran

Turk J Anaesthesiol Reanim 2021; 49: 470-476
DOI: 10.5152/TJAR.2021.1172
Read: 148 Downloads: 95 Published: 01 December 2021

Objective: Back pain is reported to be the fifth most common reason for referral a patient to a physician and the most common disability in modern society. The present study aimed to evaluate the effects of calcitonin addition on epidural injection in patients with degenerative spinal canal stenosis in comparison with epidural triamcinolone injection.

Materials and methods:The clinical trial study was performed on 40 patients with degenerative spinal stenosis, referred to pain clinic of RasoulAkram Hospital in 2018, who were randomly divided into two intervention and control groups, including 20 individuals in each group. In the intervention group, 50 units of calcitonin were injected with 8 cc of ropivacaine 0.2% while 80 mg of triamcinolone with 8 cc of ropivacaine 0.2% was injected in the control group. Functional disability was evaluated based on the Oswestry Disability Index (ODI) and pain ratings were assessed using the Visual Analogue Scale (VAS).

Results: Pain at 4 and 8 weeks after the procedure was significantly different between the two groups. A significant difference in the patient disability index was observed between two groups at 8 and 12 weeks after the procedure. On the other hand, the rate of analgesic consumption at 4, 8 and 12 weeks after the procedure was significantly decreased in the calcitonin group (P <0.001).

Conclusions: Based on our results, injection of calcitonin into the epidural space can reduce the pain of the patients and their analgesic consumption compared to the group receiving steroids through the epidural space.
Cite this article as: Rahimzadeh P, Mahvadi SM, Mahmoudi K, et al. Effects of calcitonin addition on epidural injection in patients with degenerative spinal canal stenosis: a randomized double blind clinical trial. Turk J Anaesthesiol Reanim. 2021;49(6):470-476.

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