Turkish Journal of Anaesthesiology & Reanimation
Cardiovascular and Thoracic Anaesthesia - ORIGINAL ARTICLE

N-Acetylcysteine Supplementation for the Prevention of Postoperative Liver Dysfunction after On-Pump Cardiac Surgery

1.

Department of Anaesthsiology and Crtitical Care, Vivekanand Polyclinic Institute of Medical Sciences, Lucknow, India

2.

Department of Anaesthsiology and Crtitical Care Medicine, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India

3.

Department of Cardiothoracic and Vascular Surgery, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India

Turk J Anaesthesiol Reanim 2021; 49: 460-469
DOI: 10.5152/TJAR.2021.21370
Read: 410 Downloads: 36 Published: 07 May 2021

Introduction: Incidence of postoperative liver dysfunction continues to be high (ranging from 10-35%) in those who underwent cardiac surgeries using cardiopulmonary bypass (CPB) and is associated with considerable morbidity and mortality. Prolonged cardiopulmonary bypass time (CPBT) was found to be an independent predictor of postoperative liver dysfunction. So, the aim of the study was to evaluate the effect of prophylactic use of N-acetylcysteine (NAC) in patients undergoing on-pump cardiac surgery with expected prolonged CPBT in prevention of liver dysfunction.

Methods: 60 consenting adult patients undergoing cardiac surgeries using CPB with CPBT more than 120 mins were included in this single-centre, randomized, parallel-group, double blind interventional study. Study group patients received NAC as per protocol. Liver transferases, alkaline phosphatase, serum bilirubin, kidney function tests and coagulation parameters were measured preoperatively, on the day of surgery and for three days postoperatively.

Results: Values for serum ALT, AST and ALP were significantly raised in the control group compared to the study group, starting from the day of surgery till 3rd postoperative day. Serum bilirubin level (total and direct) were comparable till first postoperative day and were significantly raised on second and third postoperative days in the control group. Duration of mechanical ventilation, total chest tube drainage, duration of ICU and hospital stay were significantly shorter in study group compared to control group.

Conclusion: Prophylactic intravenous NAC has a protective role in preventing postoperative hepatic dysfunction in patients undergoing cardiac surgery with cardiopulmonary bypass.

Cite this article as: Kumar R, Bansal M, Nath SS, Kumar V, Malviya D, Srivastava D. N-Acetylcysteine Supplementation for the Prevention of Postoperative Liver Dysfunction after On-Pump Cardiac Surgery. Turk J Anaesthesiol Reanim. 2021;49(6):460-469.

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