Objective:
The incidence of acute kidney injury during the hospital stay in patients with coronavirus disease 2019 varies between 8% and 17% in studies. This rate is at the highest levels among the critical patient group monitored in the intensive care unit (23% [14-35%]). In this study, we aimed to assess the incidence of acute kidney injury development, effective factors, and clinical outcomes of patients monitored in the intensive care unit due to coronavirus disease 2019.
Methods:
A total of 801 patients were analyzed. Patients were divided into 2 groups as those developing acute kidney injury (n = 408) and those not developing acute kidney injury (n=393). Patients developing acute kidney injury were staged according to the Kidney Disease Improving Global Outcomes criteria.
Results:
In all patients, the mortality rate was 65.2%. The mortality rate for those developing acute kidney injury was identified to be high by a statistically significant degree compared to those not developing acute kidney injury. The mortality rate in Kidney Disease Improving Global Outcomes criteria stage 1 was 81.3%, in stage 2 was 88.3%, and in stage 3 was 91.5%. The frequency of diabetes mellitus type 2, coronary artery disease, and chronic obstructive pulmonary disease in the group developing acute kidney injury was found to be statistically significantly higher. We have found positive correlations between acute kidney injury development and age, sex, history of diabetes mellitus, and ferritin levels in the multivariate analysis.
Conclusions:
The development of acute kidney injury in intensive care unit patients with coronavirus disease 2019 is associated with increased mortality. Therefore, predisposing factors should be determined and effective treatment strategies should be established in the early period.
Keywords: Acute kidney injury, COVID-19, intensive care unit, mortality, pandemic