Objective:
To investigate the effects of pre-emptive intravenous 50 mg dexketoprofen application on postoperative pain scores, morphine consumption on patient controlled analgesia, postoperative patient satisfaction, mobilisation and length of hospital stay with adverse effects.
Methods:
In this double blind, randomised study, 90 ASA I-II patients, aged 20-70 years, who were scheduled for elective laparotomy were enrolled. The patients were divided into three groups. In group Dpre, 50 mg dexketoprofen in 100 mL saline was given 30 minutes prior to surgical incision, in group Dpost, 50 mg dexketoprofen in 100 mL saline was given 30 minutes prior to skin closure, and in group C (Control) 100 mL saline was given 30 minutes prior to surgical incision and skin closure. Intraoperative haemodynamic parameters and postoperative pain scores, sedation scores, morphine consumption, and adverse effects were recorded.
Results:
When compared with other groups, total morphine consumption in the postoperative 24 hours was lower in group Dpre (p<0.01 for both groups). In group Dpre, the first mobilisation time was shorter than other groups (for both groups p<0.01). There was no difference in the length of hospital stay among three groups (p>0.05). Patient satisfaction scores were lower in Group C (for both groups p<0.05).
Conclusion:
We observed that the administration of pre-emptive intravenous 50 mg dexketoprofen trometamol provides effective analgesia with decreasing postoperative opioid consumption.
Keywords: Pre-emptive analgesia, dexketoprofen trometamol, postoperative analgesia