Original Article

Comparison of the Effects of Dexmedetomidine and Remifentanyl on Haemodynamics, Awakening and Recovery in Tympanoplasty and Tympanomasteidectomy


  • Şaziye Ebru Adıgüzel
  • Öznur Şen
  • Gülay Özkaya
  • Gülşen Bican

Received Date: 17.05.2011 Accepted Date: 11.06.2012 Turk J Anaesthesiol Reanim 2013;41(1):14-17


The aim of this study is to compare the effects of deksmededetomidin and remifentanyl which are used to induce controlled hypotension, on peroperative haemodynamic chages, awakening, and recovery time and Aldrete sedation score in tympanoplasty- tympanomastoidectomy surgery.


This randomized double blind study was conducted with 50 ASA I-II patients scheduled for tympanoplasty-tympanomastoidectomy surgery. The patients were randomly allocated to one of 2 groups: Group R and Group D. Group R received remifentanil HCL at the rate of 0.2 mg kg-1 min-1 and Group D received deksmedetomidin at the loading dose of 1 mg kg-1 within 10 minutes. The first haemodynamic parameters of the patients were recorded as basal values, after bolus infusion and intubation and during the perioperative period were recorded every fifteen minutes. At the end of surgery, before and after extubation, and also until 60th minute after extubation, parameters were recorded every 5 minutes. The number of minutes elapsed before patients had spontaneous inspiration after infusion was stopped, opened their eyes, were extubated and were able to obey commands were all recorded. Aldrete sedation score was evaluated at the postoperative 30th minute.


There were no differences between the two groups with respect to basal values and post-extubation heart rate and mean arterial pressure values, beginning of spontaneous inspiration, eye opening, obeying commands, extubation time and Aldrete Sedation Score levels.


We concluded that there was no superiority of deksmedetomidine or remifentanilin to each other in inducing controlled hypotension and also, they can be safely used for this purpose.

Keywords: Dexmedetomidine, remifentanyl, controled hypotension, haemodynamics