Objective:

Our goal is to evaluate the neuromuscular blocking effects of rocuronium with inhalation anesthetic sevoflurane and intravenous anesthetic propofol and midazolam via accelomyographic method.

Materials and Methods:

Sixty patients aged 18-65 years undergoing extrathoracic and extraabdominal surgery with ASA I-II were included in the study and randomised into 3 groups. For induction. Propofol and remifentanil were used in Sevoflurane and Propofol groups and midazolam and remifentanil were used in the Midazolam group respectively. Anesthesia maintenance were done with sevoflurane, nitrous oxide and O2 inhalation in the Sevoflurane group, propofol, and remifentanil in the Propofol group and midazolam, and remifentanil infusion in Midazolam group. O2 and air inhalation in Propofol and Midazolam groups. Hundred µg kg-1 increasing doses of rocuronium were infused as the TW response of adductor pollicis muscle created by the neuromuscular stimulus were evaluated. Rocuronium infusion were stopped as soon as the TW response were depressed over % 95. Duration, recovery index and TOF % 70 time were recorded. ED50 and ED95 doses of rocuronium for specific groups were calculated with the Probit transformation method.

Results:

In the Sevoflurane group, the ED50 and ED95 values of rocuronium were statistically significantly decreased relative to Propofol and Midazolam groups. In Midazolam and Propofol groups, the ED50 and ED95 values of rocuronium did not differ from each other statistically. In the Sevoflurane group; duration of clinical effectiveness of sevoflurane, recovery index and TOF 70 % time were significantly increased comparing to Propofol and Midazolom groups. Any difference in terms of these parameters did not exist between Propofol, and Midazolam groups.

Conclusion:

In the sevoflurane group, rocuronium’s neuromuscular blocking effects were significantly increased comparing to midazolam and propofol. Between midazolam and propofol no difference were detected as for measured parameters.

Keywords: Anesthetics-intravenous, anesthetics-inhalation, neuromuscular blocking agent, rocuronium