ABSTRACT

Propofol is an anesthetic agent used frequently for the induction and maintenance of anesthesia, and sedation as well. Its most important side effects are injection pain, and hemodynamic side-effects. There are reports stating that with a new formula (Propofol-Lipuro) injection pain is reduced. In our study the effects of sub-anesthetic dose of propofol and Propofol-Lipuro on injection pain and hemodynamic response have been compared.

To 75 patients included in the study, 2 mL 1 % propofol (Group P), and to another 75 cases 2 mL 1 % Propofol-Lipuro (Group PL) were administered at a rate of 1 mL s-1. Pain scores and hemodynamic findings at the postinjection 5th secs were recorded.

While all the patients in Group P felt injection pain, 17 patients in Group PL (22.7 %) did not feel any pain at all (p<0.05). Severe pain was felt by 44 (58.7 %) in patients Group P, and only 20 cases (26.7 %) in Group PL (p<0.05). Hemodynamic response was similar in both groups.

Propofol-Lipuro can be preferred over propofol due to its milder injection pain.

Keywords: Propofol, Propofol-Lipuro, pain