Efficacy of Hyaluronidase in the Mannitol Extravasation Induced Compartment Syndrome-A Case Report and Review of Literature
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Case Report
P: 329-333
August 2021

Efficacy of Hyaluronidase in the Mannitol Extravasation Induced Compartment Syndrome-A Case Report and Review of Literature

Turk J Anaesthesiol Reanim 2021;49(4):329-333
1. Department of Anesthesia & Critical Care, All India Institute of Medical Sciences (AIIMS), Jodhpur, India
2. Department of Neurosurgery, All India Institute of Medical Sciences (AIIMS), Jodhpur, India
No information available.
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Received Date: 19.04.2020
Accepted Date: 30.05.2020
Publish Date: 03.08.2021
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ABSTRACT

Mannitol is one of the indispensable drugs in neurosurgery to manage the raised intracranial pressure. Though considered safe, extravasation of mannitol into the tissues can cause considerable morbidity with the consequent development of compartment syndrome. We report a case of a 50-year-old female who developed forearm compartment syndrome due to mannitol extravasation after undergoing surgery for frontal glioma under general anaesthesia. The severe forearm compartment syndrome could be successfully managed without fasciotomy using hyaluronidase. We describe the pathophysiology, prevention and treatment strategies emphasising the use of hyaluronidase in the management of mannitol extravasation induced compartment syndrome.