The Effect of Temperature Changes on Densities of Local Anesthetic/Opioid Mixtures
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Original Article
P: 279-283
October 2012

The Effect of Temperature Changes on Densities of Local Anesthetic/Opioid Mixtures

Turk J Anaesthesiol Reanim 2012;40(5):279-283
1. Fatih Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı, Ankara, Türkiye
2. Ankara Onkoloji Hastanesi, Anestezi Bölümü, Ankara, Türkiye
No information available.
No information available
Received Date: 20.12.2011
Accepted Date: 29.02.2012
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ABSTRACT

Objective:

The density of local anesthetics (LA) and opioids may be influenced by the temperature of the solution. The aim of the study is to analyze the density of LA/opioid mixtures at different temperatures.

Methods:

Densities of LA/opioid mixtures that are used in spinal anesthesia such as bupivacaine 0.5%, bupivacaine hyperbaric 0.5%, levobupivacaine 0.5%, prilocaine 2%, lidocaine 2%, articaine 2%, fentanyl and morphine were measured. The measurements were made using a picnometer at 5°, 10°, 15°, 20°, 25°, 30° and 37°C temperatures.

Results:

The densities of the LA/opioid mixtures except bupivacaine hyperbaric 0.5% were hypobaric at 37°C while their densities were hyperbaric at 25°C and colder temperatures. Adding fentanyl to local anesthetics decreased the density of the mixtures, while adding morphine increased the density of the mixtures except for bupivacaine hyperbaric 0.5%.

Conclusion:

Densities of LA/opioid mixtures increase by cooling from 37°C to 5°C. The addition of opioids in LA changes the densities of LAs.

Keywords: Local anesthetic, opioids, temperature

References

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