Turkish Journal of Anaesthesiology & Reanimation

Anaesthesia-Related Pediatric Neurotoxicity: A Survey Study


Department of Anaesthesiology and Reanimation, Health and Science University, Konya City Hospital, Konya, Turkey


Department of Anaesthesiology and Reanimation, Bursa Gürsu State Hospital, Bursa, Turkey


Department of Pediatric Surgery, Selçuk University Medical School, Konya, Turkey

Turk J Anaesthesiol Reanim 2022; 50: 121-128
DOI: 10.5152/TJAR.2022.21602
Read: 350 Downloads: 99 Published: 21 April 2022

Objective: Millions of children are exposed to anaesthetic drugs every day; however, the possible adverse effects of these agents on the central nervous system remain controversial. This study evaluated anaesthesiologists’ and pediatric surgeons’ knowledge and daily practices regarding anaesthesia-induced neurotoxicity.

Methods: A survey consisting of 12 questions was sent to members of the Turkish Anaesthesiology and Reanimation Association and the Turkish Pediatric Surgery Association via the Google forms program.

Results: A total of 202 anaesthesiologists and 51 pediatric surgeons participated in this survey. The results demonstrate that anaesthesiologists and surgeons are aware of the risk of anaesthesia-related neurotoxicity and are willing to take action. Approximately, half of the anaesthesiologists and pediatric surgeons expected to postpone operations lasting at least 3 hours for patients <3 years of age. Also, one-third of the anaesthesiologists would seek feasible and more reliable alternative anaesthetic strategies.

Conclusions: More than two-thirds of the participants knew about the US Food and Drug Administration neurotoxicity warning; however, uncertainty about anaesthesia-related neurotoxicity is ongoing. Many questions remain unanswered. The results of large-scale prospective randomized studies to evaluate the effect of anaesthetics and surgery on the cognitive development of pediatric patients are needed.

Cite this article as: Yıldız M, Kozanhan B, Aydoğan E, Tire Y, Sekmenli T. Anaesthesia-related pediatric neurotoxicity: A survey study. Turk J Anaesthesiol Reanim. 2022;50(2):121-128.

EISSN 2667-6370