Turkish Journal of Anaesthesiology & Reanimation

Severe Metabolic Acidosis, Acute Renal Failure, and Delayed Paralysis Leading to Respiratory Depression due to Manganese ethylene-bis-dithiocarbamate


Nephrology Clinic, Kocaeli State Hospital, Kocaeli, Turkey


Department of Endocrinology and Metabolism, İstanbul University Faculty of Medicine, İstanbul, Turkey


University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey

Turk J Anaesthesiol Reanim 2023; 51: 62-64
DOI: 10.5152/TJAR.2023.21596
Read: 33 Downloads: 30 Published: 01 February 2023

Maneb is a widely used agricultural fungicide, which can lead to parkinsonism due to its neurotoxic effects on the dopaminergic system after chronic low-dose exposure. Previous acute human maneb poisoning cases occurred with low-dose maneb exposure through the dermal route causing renal failure. This report presents a case of acute renal failure and delayed paralysis due to ingestion of a large dose of maneb for a suicide attempt. A 16-year-old female patient was admitted to the emergency room because of drinking almost a whole bottle of maneb (400 mL [2 g L−1]) about 2 hours before. The patient was transferred to the intensive care unit with severe metabolic acidosis and renal failure. On the 4th day in intensive care unit, although the severe acidosis was resolved with haemodialysis, the patient was intubated because of ascending muscle weakness and dyspnoea. After staying in the intensive care unit for 9 days and in the nephrology ward for 2 weeks, the patient was discharged well from the hospital with no further need for haemodialysis but a persistent bilateral drop foot. One year after the event, renal functions were normal, and motor function in the lower extremities improved entirely.

Cite this article as: Güven Taymez D, Telci Çaklılı Ö, Gürbüz H. Severe metabolic acidosis, acute renal failure, and delayed paralysis leading to respiratory depression due to manganese ethyl ene-b is-di thioc arbam ate. Turk J Anaesthesiol Reanim. 2023;51(1):62-64.

EISSN 2667-6370